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NICE Underpinning Review
Electronic cigarettes (e-cigarettes) are a relatively new technology. Commonly used pharmacotherapies for cessation include NRT, varenicline and bupropion. The relative effectiveness of these treatments compared with e-cigarettes is unclear and may affect patient choice. The main aim of this review is to establish which interventions are the most effective and cost effective for cessation at 6 months. The review will also separately consider the effectiveness of e-cigarettes for shorter term cessation (1-<6 months; question 1a.i.) to compare with the longer term results.
This evidence review supports recommendations 1.12.1 to 1.12.6, 1.12.13 to 1.12.17, 1.14.19, 1.22.1 to 1.22.2, 1.22.14, and the research recommendations on health effects of e-cigarettes, stop-smoking interventions for under-served groups, support for people with mental health conditions to stop smoking, e-cigarettes for harm reduction, use of e-cigarettes (amount and frequency), and e-cigarette flavours. Other evidence supporting these recommendations can be found in the evidence reviews on barriers and facilitators to e-cigarettes (review L), long-term health effects of e-cigarettes (review M), smoking relapse prevention (review N) and tailored interventions for those with mental health conditions (review O).